Diabetic mice attained the blood sugar levels ranging from 220mgdl to. After acclimatization, 25 swiss albino male mice mus musculus were randomly divided. Mcp was orally administered once a day after 3 days of alloxaninduction at 100, 200 and 300 mgkg body weight for 28 day. It is better to standardize it first by jain et al. Alloxaninduced diabetes, a common model for evaluating. Blood glucose levels and body weights of control and diabetic mice were monitored.
In diabetic rats, the fasting blood glucose level, indexes of heart and liver, and levels. The mice were subjected to 18 h of fasting before each test was carried out. Hypoglycemic activity of aqueous extract of pleurotus pulmonarius. Diabetic mice attained the blood sugar levels ranging from 220mgdl to 350mgdl. Effect of methanolic extract of passiflora foetida on. A watersoluble polysaccharide mcp was isolated from the fruits of momordica charantia l. Pdf medicinal plants play an important role in the management of diabetes mellitus especially in. Sufiyansiddiqui, 1 gurudayalram, 2 ranjeetkumaryadav, 1 artikumari, 3 gauravsharma, 4 andnakuleshwardutjasuja 4. In the present study activities of liver enzymes such as glucokinase, glucose 6 phosphatase and fructose 1 6diphosphatase were also determined. Sir, we read with interest the article titled anomalies in alloxaninduced diabetic model. Effect of 30 day administration of prebiotic beverage on alloxaninduced diabetic rat on the following parameters a catalase activity u. Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse. Alloxan has been administered in single or multiple doses, through different routes intraperitoneal.
Group 1 was the normal control mice that received distilled water as placebo while groups 26 were diabetic mice. Antidiabetic effect of neem and spirulina in alloxan. Arika wm, abdirahman ya, mawia mm, wambua kf, nyamai dm, et al. We used alloxan to induce diabetes in rats and rabbits for screening the antidiabetic activity of test compounds. Hypoglycemic effect of aqueous and ethyl acetate leaf extract of.
The responses are accompanied by corresponding inverse changes in plasma insulin and sequential ultrastructural. Hypoglycemic effects in alloxaninduced diabetic rats of the. Hypoglycemic effect of lippia javanica in alloxan induced. According to articles i found that suggested dose to induce diabetes 1 in albino rats is about 140 mgkg. Antihyperglycemic activity, lagerstroemia speciosa, diabetes mellitus, alloxaninduced diabetes. Alloxan monohydrate induces diabetes in animals, although streptozotocin. Effect of aloe vera leaf extract on alloxan induced. Balbc mice 8 weeks old, 1822 g were purchased from the animal house in the institute of bioscience, university putra malaysia.
The crude methanol extract of heliotropium strigosum hs. After acclimatization, 25 swiss albino male mice mus musculus were randomly divided into five equal groups, from which one was kept as. Hypoglycemic effects in alloxaninduced diabetic rats of the phenolic extract. Dose optimization of alloxan for diabetes in albino mice. Pdf experimental diabetes induced by alloxan and streptozotocin. Research article alloxan induced diabetes mellitus in. The mechanisms of alloxan and streptozotocininduced diabetes. In this study the antidiabetic effects of neem and spirulina were evaluated in alloxaninduced diabetic mice. Passiflora edulis, antidiabetic, hyperglycemia, alloxan mono hydrate introduction nsulin is the principal hormone secreted by. Antidiabetic effect of ethanolic leaf extract of phyllanthus amarus in. Hypoglycemic effect of ocimum lamiifolium in alloxan. Effect of luff aegyptica leaf extract on body weigh in alloxan induced diabetic rats. The experiments were evaluated on normoglycemic, glucoseinduced hyperglycemic, and alloxaninduced diabetic mice. Research article rejuvenating of kidney tissues on alloxan.
Alloxan diabetes and streptozotocin diabetes figure 1 shows a schematic diagram of the tetraphasic and triphasic blood glucose responses induced by alloxan and streptozotocin, respectively, when injected 22. Diabetes was induced in balbc mice by injecting alloxan 200 mgkg i. Antihyperglycemic effects of fermented and nonfermented. Pdf antidiabetic potential of caralluma europaea against alloxan. Diabetes was induced in mice by a single intravenous injection of aqueous alloxan monohydrate 70 mgkg, i. Pdf hypoglycemic effect of lagerstroemia speciosa l. The antidiabetic activity was screened in alloxan induced diabetic mice through oral and intraperitoneal routes. Antioxidant and prebiotic effects of a beverage composed. Alloxaninduced diabetes delays repair in a rat model of.
Alloxaninduced diabetic mice the mice were randomly assigned into six different groups n 8. Attenuation of diabetic hepatopathy in alloxaninduced diabetic mice. Group vii consisted of alloxan induced diabetic mice either. The present investigation was carried out to evaluate the antidiabetic effect of ethanolic leaf extract of phyllanthus amarus in alloxan induced diabetic mice. It has been successfully induced in a variety of animal species.
There was statistically significant p alloxaninduced diabetes is a form of insulindependent diabetes mellitus that occurs as a result of alloxan administration or injection to animals. Show lipid peroxidation level in different group of mice. Hypoglycemic effect of semipurified peptides from an aqueous extract of momordica charantia l. The induction of diabetes mellitus aims to use animals under. Various developments from gene transplants to invitro experiments on mice have emerged 7. Diabetes mellitus dm is one of the leading causes of death and should not be left neglected. It is the most common endocrine disorder that occurs not only in the poor but also occurs greatly among the rich and all nations are suffering the impact of the diabetes epidemic 1.
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